Refine your search
Collections
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Muddukrishna, B. S.
- Computational Approach for the Design of Novel Tankyrase Inhibitors:A Rational Study based on Pharmacophore and Atom based 3D QSAR
Abstract Views :136 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal, Karnataka, IN
2 Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal, Karnataka, IN
3 Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal, Karnataka, IN
1 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal, Karnataka, IN
2 Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal, Karnataka, IN
3 Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 778-784Abstract
Pharmacophore based screening was undertaken for a set of 30 flavones exhibiting Tankyrase I inhibitory activity. The two isoenzymes Tankyrase I and Tankyrase II share 80% sequence homology. This gives rise to the fine tuning required in the designing of small molecules wchich can selectively inhibit one or the other. In a recent study it was reported that, small molecule inhibitors of Tankyrases will be benificial in certain types of cancers like colorectal cancers. In future it may be a slective target for cancers like colorectal cancer. Four feature pharmacophores with one H bond acceptor and three aromatic rings were developped.The hypothesis ARRR2 was considered as best hypothesis ,which gave a statistically significant three dimensional QSAR model with corresponding statistical parameters (0.9028 as r2 value and 0.8548 as q2 value). The generated model was applied sucessfully on a set of both training and test set molecules. The squared corelation coefficient of 0.85 was observed between actual and predicted values in test set. The squared corelation coefficient of 0.96 was observed between actual and predicted value in training set. The built model will be useful in predicting the structural requirements needed for the selective inhibition of Tankyrase I.Keywords
Tankyrase, Pharmacophore, QSAR, Flavones.- Importance of Competency Level and its Assessment in Pharmaceutical Industry
Abstract Views :179 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal -576104, Karnataka State, IN
2 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal -576104, Karnataka State, IN
1 Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal -576104, Karnataka State, IN
2 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal -576104, Karnataka State, IN
Source
Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 139-142Abstract
Both competency level and training plays a major role in pharmaceutical industries. Pharmaceutical industry employs technical people from various streams or fields like graduates and post graduates in pharmacy, engineering, science, management etc. On one hand, competency or basic education is a prerequisite for recruiting technical staff to perform assigned job, on the other hand, training the graduates from various streams is an important task for the pharmaceutical industry. Training and development is an ongoing or routine activity in pharma industry so that both the pharma companies and technical staff are up to date and meet the regulatory requirements as per norms. Even the competency level needs to be improved from time to time, like new generation smart phones, where in we need to update our smart phone to include new features or upload new software’s. If this is not done, we become outdated. Likewise, in pharmaceutical industries, both competency level and training and development go parallelly and complimentary to each other. With regulatory agencies (FDAs) becoming increasingly stringent, both competency and training have become integral part of today’s cGMP systems. Therefore, to make the technical staff more competent and well trained, this article gives a detailed insight into competency level and training and development.Keywords
Competency, Competency Level, Job Responsibility and cGMP.References
- http://pdf.usaid.gov/pdf_docs/PA00JGFN.pdf.Accessed on 11/27/2016.
- https://en.wikipedia.org/wiki/Competence. Accessed on 01/12/2016.
- https://hr.od.nih.gov/workingatnih/competencies/proficiencyscale.htm Accessed on 21/12/2016.
- http://www.aspiringminds.com/featured-profiles/pharmaceutical-trainee-entry-level-0. Accessed on 27/01/2017.